| English Premier League |
| No. | Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 1 | 14-Aug-11 | A | West Bromwich Albion | W | 2-1 | (1-1) | Rooney 13; Reid(og) 81 | 25,360 |
| 2 | 22-Aug-11 | H | Tottenham Hotspur | W | 3-0 | (0-0) | Welbeck 61; Anderson 76; Rooney 87 | 75,498 |
| 3 | 28-Aug-11 | H | Arsenal | W | 8-2 | (3-1) | Welbeck 22; Young 28, 90; Rooney 41, 64, 82p; Nani 67; Park 70 | 75,448 |
| 4 | 10-Sep-11 | A | Bolton Wanderers | W | 5-0 | (3-0) | Hernandez 5, 58; Rooney 20, 25, 68 | 25,944 |
| 5 | 18-Sep-11 | H | Chelsea | W | 3-1 | (3-0) | Smalling 8; Nani 37; Rooney 45 | 75,455 |
| 6 | 24-Sep-11 | A | Stoke City | D | 1-1 | (1-0) | Nani 27 | 27,582 |
| 7 | 01-Oct-11 | H | Norwich City | W | 2-0 | (0-0) | Anderson 68; Welbeck 87 | 75,514 |
| 8 | 15-Oct-11 | A | Liverpool | D | 1-1 | (0-0) | Hernandez 81 | 45,065 |
| 9 | 23-Oct-11 | H | Manchester City | L | 1-6 | (0-1) | Fletcher 81 | 75,487 |
| 10 | 29-Oct-11 | A | Everton | W | 1-0 | (1-0) | Hernandez 19 | 35,494 |
| 11 | 05-Nov-11 | H | Sunderland | W | 1-0 | (1-0) | Brown(og) 45 | 75,570 |
| 12 | 19-Nov-11 | A | Swansea City | W | 1-0 | (1-0) | Hernandez 11 | 20,295 |
| 13 | 26-Nov-11 | H | Newcastle United | D | 1-1 | (0-0) | Hernandez 49 | 75,594 |
| 14 | 03-Dec-11 | A | Aston Villa | W | 1-0 | (1-0) | Jones 20 | 40,053 |
| 15 | 10-Dec-11 | H | Wolverhampton Wndrs | W | 4-1 | (2-0) | Nani 17, 56; Rooney 27, 62 | 75,627 |
| 16 | 18-Dec-11 | A | Queens Park Rangers | W | 2-0 | (1-0) | Rooney 1; Carrick 56 | 18,033 |
| 17 | 21-Dec-11 | A | Fulham | W | 5-0 | (3-0) | Welbeck 5; Nani 28; Giggs 43; Rooney 88; Berbatov 90 | 25,700 |
| 18 | 26-Dec-11 | H | Wigan Athletic | W | 5-0 | (2-0) | Park 8; Berbatov 41, 58, 78p; Valencia 75 | 75,183 |
| 19 | 31-Dec-11 | H | Blackburn Rovers | L | 2-3 | (0-1) | Berbatov 52, 62 | 75,146 |
| 20 | 04-Jan-12 | A | Newcastle United | L | 0-3 | (0-1) | | 52,299 |
| 21 | 14-Jan-12 | H | Bolton Wanderers | W | 3-0 | (1-0) | Scholes 45; Welbeck 74; Carrick 83 | 75,444 |
| 22 | 22-Jan-12 | A | Arsenal | W | 2-1 | (1-0) | Valencia 45; Welbeck 81 | 60,093 |
| 23 | 31-Jan-12 | H | Stoke City | W | 2-0 | (1-0) | Hernandez 38p; Berbatov 53p | 74,719 |
| 24 | 05-Feb-12 | A | Chelsea | D | 3-3 | (0-1) | Rooney 58p, 69p; Hernandez 84 | 41,668 |
| 25 | 11-Feb-12 | H | Liverpool | W | 2-1 | (0-0) | Rooney 47, 50 | 74,844 |
| 26 | 26-Feb-12 | A | Norwich City | W | 2-1 | (1-0) | Scholes 7; Giggs 90 | 26,811 |
| 27 | 04-Mar-12 | A | Tottenham Hotspur | W | 3-1 | (1-0) | Rooney 45; Young 60, 69 | 36,034 |
| 28 | 11-Mar-12 | H | West Bromwich Albion | W | 2-0 | (1-0) | Rooney 35, 71p | 75,598 |
| 29 | 18-Mar-12 | A | Wolverhampton Wndrs | W | 5-0 | (3-0) | Evans 21; Valencia 43; Welbeck 45; Hernandez 56, 61 | 27,290 |
| 30 | 26-Mar-12 | H | Fulham | W | 1-0 | (1-0) | Rooney 42 | 75,570 |
| 31 | 02-Apr-12 | A | Blackburn Rovers | W | 2-0 | (0-0) | Valencia 81; Young 86 | 26,532 |
| 32 | 08-Apr-12 | H | Queens Park Rangers | W | 2-0 | (1-0) | Rooney 15p; Scholes 68 | 75,505 |
| 33 | 11-Apr-12 | A | Wigan Athletic | L | 0-1 | (0-0) | | 18,115 |
| 34 | 15-Apr-12 | H | Aston Villa | W | 4-0 | (2-0) | Rooney 7p, 73; Welbeck 43; Nani 90 | 75,138 |
| 35 | 22-Apr-12 | H | Everton | D | 4-4 | (1-1) | Rooney 41, 69; Welbeck 57; Nani 60 | 75,522 |
| 36 | 30-Apr-12 | A | Manchester City | L | 0-1 | (0-1) | | 47,259 |
| 37 | 06-May-12 | H | Swansea City | W | 2-0 | (2-0) | Scholes 28; Young 41 | 75,496 |
| 38 | 13-May-12 | A | Sunderland | W | 1-0 | (1-0) | Rooney 20 | 46,452 |
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|
| FA Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 3 | 08-Jan-12 | A | Manchester City | W | 3-2 | (3-0) | Rooney 10, 40; Welbeck 30 | 46,808 |
| 4 | 28-Jan-12 | A | Liverpool | L | 1-2 | (1-1) | Park 39 | 43,952 |
|
|
| League Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 3 | 20-Sep-11 | A | Leeds United | W | 3-0 | (3-0) | Owen 15, 32p; Giggs 45 | 31,031 |
| 4 | 25-Oct-11 | A | Aldershot Town | W | 3-0 | (2-0) | Berbatov 15; Owen 41; Valencia 48 | 7,044 |
| QF | 30-Nov-11 | H | Crystal Palace | L | 1-2 | (0-0) | Macheda 69p | 52,624 |
|
|
| Community Shield |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| F | 07-Aug-11 | A | Manchester City | W | 3-2 | (0-2) | Smalling 52; Nani 58, 90 | 77,169 |
|
|
| Europa League Finals |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 2 L1 | 16-Feb-12 | A | Ajax | W | 2-0 | (0-0) | Young 59; Hernandez 85 | 51,000 |
| 2 L2 | 23-Feb-12 | H | Ajax | L | 1-2 | (1-1) | Hernandez 6 | 67,328 |
| 3 L1 | 08-Mar-12 | H | Athletic Bilbao | L | 2-3 | (1-1) | Rooney 22, 90p | --,--- |
| 3 L2 | 15-Mar-12 | A | Athletic Bilbao | L | 1-2 | (0-1) | Rooney 80 | 40,000 |
|
|
| UEFA Champions League |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 1 Gp c | 14-Sep-11 | A | Benfica | D | 1-1 | (1-1) | Giggs 42 | 59,671 |
| 1 Gp c | 27-Sep-11 | H | FC Basel | D | 3-3 | (2-0) | Welbeck 16, 17; Young 90 | 73,115 |
| 1 Gp c | 18-Oct-11 | A | Otelul Galati | W | 2-0 | (0-0) | Rooney 64p, 90p | 49,500 |
| 1 Gp c | 02-Nov-11 | H | Otelul Galati | W | 2-0 | (1-0) | Valencia 8; Rooney 87 | 74,847 |
| 1 Gp c | 22-Nov-11 | H | Benfica | D | 2-2 | (1-1) | Berbatov 30; Fletcher 59 | 74,853 |
| 1 Gp c | 07-Dec-11 | A | FC Basel | L | 1-2 | (0-1) | Jones 89 | 36,894 |
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Score distributions by match - goals scored by row, and goals conceded by column. Each box shows the number of this season's matches with the resulting scoreline.