| Spanish Primera Liga |
| No. | Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 1 | 30-Aug-09 | A | Valencia | L | 0-2 | (0-0) | | 50,000 |
| 2 | 12-Sep-09 | H | Real Zaragoza | W | 4-1 | (2-1) | Konko 8; Luis Fabiano 45, 87; Perotti 57 | 49,500 |
| 3 | 19-Sep-09 | A | Osasuna | W | 2-0 | (1-0) | Negredo 37; Kanoute 71 | 28,000 |
| 4 | 22-Sep-09 | H | Real Mallorca | W | 2-0 | (2-0) | Squillaci 17; Perotti 26 | 48,000 |
| 5 | 26-Sep-09 | A | Athletic Bilbao | W | 4-0 | (3-0) | Renato 5; Negredo 21; Kanoute 45; Jesus Navas 75 | 39,000 |
| 6 | 04-Oct-09 | H | Real Madrid | W | 2-1 | (1-0) | Jesus Navas 33; Renato 67 | 45,000 |
| 7 | 17-Oct-09 | A | Deportivo | L | 0-1 | (0-1) | | 25,000 |
| 8 | 24-Oct-09 | H | Espanyol | D | 0-0 | (0-0) | | 50,000 |
| 9 | 31-Oct-09 | A | Xerez | W | 2-0 | (1-0) | Negredo 42; Luis Fabiano 90 | 18,522 |
| 10 | 08-Nov-09 | H | Villarreal | W | 3-2 | (1-1) | Luis Fabiano 9, 61; Kanoute 66 | 38,000 |
| 11 | 21-Nov-09 | A | CD Tenerife | W | 2-1 | (1-0) | Perotti 32; Renato 48 | 18,000 |
| 12 | 28-Nov-09 | H | Malaga | D | 2-2 | (0-2) | Luis Fabiano 58, 73 | 40,000 |
| 13 | 05-Dec-09 | H | Real Valladolid | D | 1-1 | (1-1) | Luis Fabiano 45p | 42,000 |
| 14 | 13-Dec-09 | A | Sporting Gijon | W | 1-0 | (1-0) | Kanoute 9 | 15,000 |
| 15 | 19-Dec-09 | H | Getafe | L | 1-2 | (0-2) | Negredo 52 | 38,000 |
| 16 | 02-Jan-10 | A | Atletico Madrid | L | 1-2 | (1-0) | Renato 44 | 35,000 |
| 17 | 09-Jan-10 | H | Racing Santander | L | 1-2 | (0-2) | Romaric 63 | 40,000 |
| 18 | 16-Jan-10 | A | Barcelona | L | 0-4 | (0-0) | | 63,274 |
| 19 | 23-Jan-10 | H | Almeria | W | 1-0 | (1-0) | Negredo 10 | 35,000 |
| 20 | 31-Jan-10 | H | Valencia | W | 2-1 | (1-0) | Negredo 21, 69 | 36,000 |
| 21 | 07-Feb-10 | A | Real Zaragoza | L | 1-2 | (1-2) | Kanoute 34 | 29,000 |
| 22 | 14-Feb-10 | H | Osasuna | W | 1-0 | (1-0) | Luis Fabiano 34 | 40,000 |
| 23 | 20-Feb-10 | A | Real Mallorca | W | 3-1 | (1-1) | Jesus Navas 23; Dragutinovic 57; Perotti 62 | 10,000 |
| 24 | 28-Feb-10 | H | Athletic Bilbao | D | 0-0 | (0-0) | | 20,000 |
| 25 | 06-Mar-10 | A | Real Madrid | L | 2-3 | (1-0) | Alonso(og) 10; Dragutinovic 53 | 75,000 |
| 26 | 13-Mar-10 | H | Deportivo | D | 1-1 | (1-1) | Fazio 21 | 40,000 |
| 27 | 20-Mar-10 | A | Espanyol | L | 0-2 | (0-1) | | --,--- |
|
|
| Spanish Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 4 L1 | 27-Oct-09 | A | Atletico Ciudad | W | 4-2 | (4-2) | Luis Fabiano 19, 20; Navas 28; Capel 36 | --,--- |
| 4 L2 | 10-Nov-09 | H | Atletico Ciudad | W | 5-1 | (0-0) | Navas 51; Luis Fabiano 53; Carlos 56, 90; Kanoute 58p | --,--- |
| 5 L1 | 05-Jan-10 | A | Barcelona | W | 2-1 | (0-0) | Capel 60; Negredo 75p | --,--- |
| 5 L2 | 13-Jan-10 | H | Barcelona | L | 0-1 | (0-0) | | --,--- |
| QF L1 | 20-Jan-10 | A | Deportivo | W | 3-0 | (1-0) | Negredo 27; Renato 68; Navas 69 | --,--- |
| QF L2 | 27-Jan-10 | H | Deportivo | L | 0-1 | (0-1) | | --,--- |
| SF L1 | 03-Feb-10 | H | Getafe | W | 2-0 | (1-0) | Luis Fabiano 45; Mario(og) 80 | --,--- |
| SF L2 | 10-Feb-10 | A | Getafe | L | 0-1 | (0-0) | | --,--- |
|
|
| UEFA Champions League |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 1 Gp g | 16-Sep-09 | H | Unirea Urziceni | W | 2-0 | (1-0) | Luis Fabiano 45; Renato 70 | 37,500 |
| 1 Gp g | 29-Sep-09 | A | Rangers | W | 4-1 | (0-0) | Konko 50; Adriano Correia 64; Luis Fabiano 72; Kanoute 74 | 40,572 |
| 1 Gp g | 20-Oct-09 | A | Stuttgart | W | 3-1 | (1-0) | Squillaci 23, 72; Jesus Navas 55 | 40,000 |
| 1 Gp g | 04-Nov-09 | H | Stuttgart | D | 1-1 | (1-0) | Jesus Navas 14 | 43,200 |
| 1 Gp g | 24-Nov-09 | A | Unirea Urziceni | L | 0-1 | (0-1) | | 5,000 |
| 1 Gp g | 09-Dec-09 | H | Rangers | W | 1-0 | (1-0) | Kanoute 8p | 38,000 |
| PO L1 | 24-Feb-10 | A | CSKA Moscow | D | 1-1 | (1-0) | Negredo 25 | 20,000 |
| PO L2 | 16-Mar-10 | H | CSKA Moscow | L | 1-2 | (1-1) | Perotti 41 | 40,000 |
Score distributions by match - goals scored by row, and goals conceded by column. Each box shows the number of this season's matches with the resulting scoreline.